Formulation, Development and Evaluation of Epirubicine Loaded Liposomal Drug Delivery System

Authors

  • Abhimanyu Singh Rathore CHAMELI DEVI INSTITUTE OF PHARMACY, INDORE Author
  • Ashwin Sharma Chameli Devi Institute of Pharmacy, Indore Author
  • Jaydeep S Baghel Chameli Devi Institute of Pharmacy, Indore Author
  • Dheeraj Gour Chameli Devi Institute of Pharmacy, Indore Author
  • Dr. A.K. Gupta Chameli Devi Institute of Pharmacy, Indore Author

Keywords:

: Liposomes, Epirubicine Hcl, Cholesterol

Abstract

Objective: The purpose of present study was to formulate Epirubicine Hcl liposomes. In the 
present study epirubicin Hcl liposomes are formulated using various biolipids and Stabilizers 
(Positive and Negative) to check effect of drug loading and particle size
Methods: The preparation of liposomes with Soybean lecithin was prepared by dried thin film 
hydration technique using rotary evaporator. Accurately weighed quantities of Soy lecithin, 
cholesterol, Stearyl amine and Dicetylphosphate are dissolved in chloroform and rotated in a 
rota-vap by applying vacuum of about 25mmHg at 25°C, until it forms a thin film.
Results: The Morphology and surface appearance of Liposomes were examined by using SEM. 
The SEM photographs of F2 and F6 formulation showed that the particles have smooth surface. 
The assay value is determined for all the formulations from F1to F6. The assay value is within 
the limit (90%) for all the formulations.
Conclusion: From the executed experimental results, it could be concluded that the stabilizers 
like Stearylamine and Dicetylphosphate along with Soy lecithin and cholesterol were suitable 
carrier for the preparation of epirubicin Liposomes.

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Published

13-04-2024

Issue

Section

Research Articles

How to Cite

Formulation, Development and Evaluation of Epirubicine Loaded Liposomal Drug Delivery System. (2024). Research Gate: Pharmaceutical Science (ISSN: 2319-6831), 13(1), 05-10. https://www.pharmbioresearch.com/Journal%202/index.php/HomeRG/article/view/17